fm, CYP3A4 of the substrates (n = 100 individuals) used in Simcyp for simulation of DDIs
| fm, CYP3A4 | ||
|---|---|---|
| Mean (S.D.) | Median (5th–95th%) | |
| % | ||
| Alprazolam | 91.3 (14.0) | 100 (63.9–100) |
| Cyclosporine | 90.8 (21.0) | 100 (35.0–100) |
| Imipramine | 2.0 (1.7) | 1.5 (0.1–3.8) |
| Metoprolol | 14.7 (24.7) | 6.7 (1.2–100) |
| Midazolam | 83.7 (29.8) | 100 (20.0–100) |
| Omeprazole | 24.3 (20.6) | 17.6 (4.2–60.7) |
| Sildenafil | 82.3 (13.0) | 87.0 (67.7–96.5) |
| Simvastatin | 83.4 (11.7) | 86.9 (58.0–97.1) |
| Theophylline | 1.8 (1.3) | 2.1 (0–5.0) |
| Tolbutamide | 2.1 (1.2) | 1.6 (0–4.8) |
| Triazolam | 85.7 (26.4) | 100 (27.2–100) |