Absolute concentrations of the nonhydroxylated metabolites detected after multiple administration (day 1-day 2-day 3) of AD in four nonchimeric mice (Non-Chim1–Non-Chim4)
No data were available for E, A, DHT, Diol 1, Diol 2, Diol 3, or DHEA.
| hAlb | Concentrations (n = 3) | ||
|---|---|---|---|
| T | EpiT | AD | |
| ng/ml ± RSD% | |||
| Non-Chim1 | |||
| Day 1 | 70.5 ± 0.7 | 43.0 ± 2.0 | |
| Day 2 | 96.1 ± 2.1 | 22.7 ± 6.6 | |
| Day 3 | 245.1 ± 6.5 | 21.7 ± 1.7 | |
| Non-Chim2 | |||
| Day 1 | 36.8 ± 3.9 | 6.8 ± 18.9 | |
| Day 2 | 104.0 ± 8.1 | 16.0 ± 10.4 | |
| Day 3 | 49.7 ± 8.4 | 10.8 ± 13.0 | |
| Non-Chim3 | |||
| Day 1 | 10.6 ± 8.2 | 8.9 ± 7.6 | 21.0 ± 5.3 |
| Day 2 | 20.5 ± 3.4 | 10.4 ± 2.3 | 24.9 ± 1.4 |
| Day 3 | 46.3 ± 4.1 | 8.7 ± 2.2 | 20.7 ± 3.7 |
| Non-Chim4 | |||
| Day 1 | 27.8 ± 4.4 | 7.6 ± 2.5 | 17.1 ± 2.8 |
| Day 2 | 31.0 ± 5.9 | 12.3 ± 4.9 | 26.2 ± 0.8 |
| Day 3 | 82.7 ± 3.8 | 13.6 ± 0.4 | 30.3 ± 2.6 |
T, testosterone; EpiT, epitestosterone; E, etiocholanolone; A, androsterone; Diol 1, 5β-androstane-3α,17β-diol; Diol 2, 5α-androstane-3α,17β-diol; Diol 3, 5α-androstane-3β,17β-diol.