TABLE 4

Results of quantitative determination for the UGT2B subfamily

Values shown are copy number × 104 normalized with GAPDH, mean ± S.D., n = 3 to 4. Donor information is presented in Table 1.


Tissue

2B4

2B7

2B10

2B11

2B15

2B17

GAPDHa
Liver 37,900 ± 711 4220 ± 12.7 3380 ± 92.7 N.D. 18,500 ± 285 197 ± 12.6 94.8 ± 0.0
Esophagus 97.7 ± 12.4 N.D. N.D. N.D. N.D. N.D. 64.8 ± 0.6
Stomachb N.D. N.D. N.D. N.D. 2710 ± 74.7 74.7 ± 2.7 95.6 ± 8.7
Small intestine N.D. 1930 ± 7.4 N.D. N.D. 738 ± 168.5 2680 ± 2.8 124 ± 0.7
Colon N.D. 2210 ± 30.3 N.D. N.D. 543 ± 132.8 3960 ± 20.2 59.4 ± 1.0
Brain N.D. N.D. N.D. N.D. N.D. 3.97 ± 1.69 211 ± 0.3
Cerebellumb N.D. N.D. N.D. N.D. N.D. N.D. 196 ± 3.3
Thyroid N.D. N.D. N.D. N.D. N.D. N.D. 80.8 ± 0.9
Thymus 28.0 ± 7.2 N.D. N.D. N.D. N.D. 36.9 ± 4.3 99.8 ± 0.3
Breastb N.D. N.D. N.D. N.D. 2010 ± 497.7 82.7 ± 5.1 60.2 ± 0.5
Adrenalb N.D. N.D. N.D. N.D. N.D. N.D. 89.4 ± 0.8
Testes 6.55 ± 1.83 N.D. N.D. N.D. 97.2 ± 36.7 3.44 ± 0.63 438 ± 6.8
Prostate 97.8 ± 2.2 N.D. N.D. N.D. 643 ± 67.6 N.D. 45.5 ± 0.6
Ovary N.D. N.D. N.D. N.D. N.D. 29.1 ± 0.7 83.8 ± 1.7
Placenta N.D. N.D. N.D. N.D. N.D. N.D. 53.7 ± 0.3
Cervix N.D. N.D. N.D. N.D. N.D. 123 ± 2.9 89.6 ± 0.9
Heart 665 ± 14.5 N.D. N.D. N.D. N.D. N.D. 291 ± 5.2
Lung N.D. N.D. N.D. N.D. N.D. 40.0 ± 18.0 56.5 ± 0.5
Trachea 44.6 ± 24.8 N.D. N.D. N.D. 253 ± 96.2 17.0 ± 3.2 132 ± 1.4
Kidney 123 ± 98.5 4790 ± 35.9 N.D. N.D. N.D. 18.3 ± 9.1 85.8 ± 2.6
Bladder N.D. N.D. N.D. N.D. N.D. N.D. 91.6 ± 0.9
Spleen N.D. N.D. N.D. N.D. N.D. 47.7 ± 6.8 89.2 ± 1.9
Adipose
N.D.
N.D.
N.D.
N.D.
N.D.
10.2 ± 0.7
75.0 ± 1.6
  • N.D., not detected (under limit of detection).

  • a Data for GAPDH are expressed as copy number per 1 pg of total RNA.

  • b Human total RNA obtained from single donor and others was pooled human total RNA derived from three donors.