In vivo clearance values for 10 drugs investigated and the main parameters used in in vitro-in vivo extrapolation
References for plasma clearance, RB, and fup are available at http://www.pharmacy.manchester.ac.uk/capkr/.
Compound | fup | RB | fub | Observed CL |
|---|---|---|---|---|
| ml/min/kg | ||||
| Buprenorphine | 0.04 | 0.60 | 0.07 | 19 |
| Carvedilol | 0.02 | 1.00 | 0.02 | 7.8 |
| Codeine | 0.70 | 1.00 | 0.70 | 15 |
| Diclofenac | 0.005 | 0.50 | 0.009 | 3.5 |
| Gemfibrozil | 0.03 | 0.55 | 0.05 | 1.7 |
| Ketoprofen | 0.008 | 0.55 | 0.01 | 1.6 |
| Midazolam | 0.017 | 0.53 | 0.03 | 5.3 |
| Naloxone | 0.54 | 1.22 | 0.44 | 23 |
| Raloxifene | 0.05 | 1.00 | 0.05 | 735 |
| Zidovudine | 0.8 | 0.98 | 0.82 | 25 |