TABLE 1

Reversal of cytotoxicity in P-gp-expressing cells by sunitinib

Cell Line	Depsipeptide, IC₅₀^a (Relative Resistance)^b			Doxorubicin, IC₅₀^a (Relative Resistance)^b
Cell Line		Control (DMSO)	+2 μM Sunitinib	Control (DMSO)	+2 μM Sunitinib
	μM
pcDNA3.1-HEK	0.0012 ± 0.0006	0.0012 ± 0.0006	0.055 ± 0.033	0.14 ± 0.010
P-gp-HEK	0.96 ± 0.23	0.38 ± 0.17	4.4 ± 2.4	4.8 ± 3.3
	(800)	(317)	(80)	(87)

DMSO, dimethyl sulfoxide.
↵ a The values represent the mean ± S.D. of three independent experiments performed in triplicate.
↵ b Relative resistance values (in parentheses) were obtained by dividing the IC₅₀ value of the P-gp-HEK cells by the IC₅₀ value of the empty vector pcDNA3.1-transfected HEK cell line.