TABLE 2
Kinetic parameters for LK-935 metabolism by primary human hepatocytes
Parameter
1 μM
10 μM
t
1/2
(min)
6.06 ± 2.35
23.6 ± 4.93
Cl
int
(ml/min/kg)
198.7 ± 67.32
47.96 ± 9.97
Cl
H
(ml/min/kg)
10.2 ± 0.22
8.8 ± 0.35
E
(extraction ratio)
0.944
0.815