Inhibition of LK-935 metabolism by chemical inhibitors
Inhibitor | Ki Values | ||||||
|---|---|---|---|---|---|---|---|
| M1 | M2 | M3a | M3b | ||||
| μM | |||||||
| Ketoconazole (CYP3A4) | 1.33 ± 0.65 | 0.788 ± 0.063 | NI | 12.8 ± 4.09 | |||
| Pentoxyresorufin (CYP2B6) | NI | NI | NI | NI | |||
| Sulfaphenazole (CYP2C9) | 1.56 ± 0.97 | NI | 0.617 ± 0.195 | 1.04 ± 0.009 | |||
| Tranylcypromine (CYP2C19) | NI | NI | NI | NI | |||
NI, not inhibited.