TABLE 1

Fraction excreted (f_{e, Bile}) by the ablated transport pathway in each animal model and the corresponding experimentally observed fold change in biliary recovery

Please note that f_{e, Bile} values for canalicular transporters pumping directly into the bile were calculated using eq. 4.1, whereas f_{e, Bile} for basolateral transporters pumping in the opposite direction (into perfusate) were calculated using eq. 5.1. Positive fold Δ values indicate an increase in exposure, whereas decreased exposure is denoted by a negative fold Δ value. All data points were calculated using mean values reported in the literature (Takenaka et al., 1995; Xiong et al., 2002; Nezasa et al., 2006; Zamek-Gliszczynski et al., 2006b,c).