Effect of 1α, 25-(OH)2-VD3 on total bile acid synthesis in HepG2 and primary human hepatocytes
Primary human hepatocytes (#HH1393, #HH1408, #HH1410) or HepG2 cells were treated with 1α, 25-(OH)2-VD3 (100 nM) for 24 h, and total bile acids synthesized in hepatocytes were assayed and expressed as the percentage of vehicle-treated control.
Cells | Total Bile Acid Synthesis (% of control) |
|---|---|
| HepG2 | 67.3 ± 1.5 |
| HH1393 | 51 |
| HH1408 | 48 |
| HH1393 | 59 |
| Average human hepatocytes | 52.7 ± 5.7 |