Drug | hOCT1 IC50 | Mock IC50 | -Fold Changea |
---|---|---|---|
μM | μM | ||
Pentamidine | 46.2 ± 5.3 | 202.2 ± 16.4 | 4.4 |
+ Ranitidine | 109.9 ± 12.4 | 170.2 ± 25.6 | 1.5 |
Furamidine | 1.1 ± 0.05 | 10.2 ± 0.7 | 9.3 |
+ Ranitidine | 7.3 ± 0.4 | 10.3 ± 1.3 | 1.4 |
↵ a -Fold increase in the sensitivity of the transfected cells to pentamidine and furamidine cytotoxicity compared with the mock cells incubated under identical conditions.