TABLE 2

Cytotoxicity of pentamidine and furamidine in CHO-hOCT1 cells and the mock CHO cells


Drug

hOCT1 IC50

Mock IC50

-Fold Changea
μM μM
Pentamidine 46.2 ± 5.3 202.2 ± 16.4 4.4
+ Ranitidine 109.9 ± 12.4 170.2 ± 25.6 1.5
Furamidine 1.1 ± 0.05 10.2 ± 0.7 9.3
+ Ranitidine
7.3 ± 0.4
10.3 ± 1.3
1.4
  • a -Fold increase in the sensitivity of the transfected cells to pentamidine and furamidine cytotoxicity compared with the mock cells incubated under identical conditions.