Pharmacokinetic parameters of vildagliptin in plasma after a single oral dose in rat and dog
See Pharmacokinetic Analysis for definitions of PK parameters.
Pharmacokinetic Parameters | Rat | Dog |
|---|---|---|
| Oral dose (mg/kg) | 100 | 6 |
| tmax (h) | 0.5 | 1.5 |
| Cmax (ng/ml) | 3680 | 1490 |
| AUC(0-∞) (ng · h/ml) | 15,200 | 5210 |
| Apparent terminal t1/2 (h) | 5.5 | 0.97 |
| Absorption (%) | 65-69 | Complete |
| Bioavailability (%) | 45 | Complete |