Metabolites of vildagliptin in urine after an oral radiolabeled dose in rat and dog
Bold type indicates major metabolites.
Metabolite | Rat (100 mg/kg): 0-96 ha | Dog (6 mg/kg): 0-168 h | |
|---|---|---|---|
| % of dose | |||
| M14.2 | —b | 1.00 | |
| M14.9 | 0.6 | —b | |
| M15.3 | 1.2 | 14.6 | |
| M16.7 | 0.6 | 1.21 | |
| M1 | —b | —b | |
| M17.4 | —b | 1.24 | |
| M17.7 | —b | 4.38 | |
| M18.6 | —b | —b | |
| M20.9 | —b | 3.76 | |
| M20.2 | 1.5 | 0.88 | |
| M20.7 | 19.1 | 23.7 | |
| M21.6 | —b | 1.92 | |
| Vildagliptin |
15.5
|
13.6
| |