TABLE 1

Pharmacokinetic parameters for nifedipine clearance

Blood NFP levels (from Fig. 6) were used to calculate pharmacokinetic parameters, including AUC, Tmax (the time at which maximum concentration occurs), Cmax (the maximum concentration), and t1/2 (the elimination half-life). Values presented are mean ± S.D. (n = 6 for oral and n = 4 for intravenous administration). Student's t test was used for statistical analysis of differences between WT and IE-Cpr-null strains.

Strain
Treatment Route
Tmax
Cmax
t1/2
AUC0-∞
h nmol/ml h nmol · h/ml
WT Oral 0.50 4.9 ± 1.2 1.38 ± 0.74 8.0 ± 0.5
IE-Cpr-null Oral 0.50 9.0 ± 2.5a 0.91 ± 0.26 12.8 ± 2.3a
WT Intravenous 0.17 6.6 ± 1.5 0.23 ± 0.02 3.6 ± 0.8
IE-Cpr-null
Intravenous
0.17
6.6 ± 0.9
0.26 ± 0.05
3.8 ± 0.6

  • AUC, area under the concentration-time curve.

  • ↵ a p < 0.01, as compared with similarly treated WT mice.