TABLE 1

In vitro unbound fraction in plasma and blood-to-plasma concentration ratio of [14C]YM155 in mice

Means (S.D.) of triplicate experiments using pooled plasma or individual data from three animals are shown.



[14C]YM155 Concentration

10 ng/ml (0.028 μM)
100 ng/ml (0.28 μM)
1000 ng/ml (2.8 μM)
5 ng/ml (0.014 μM)
50 ng/ml (0.14 μM)
500 ng/ml (1.4 μM)
Unbound fraction, % 77.62 (1.38) 79.14 (1.05) 81.40 (1.32)
Blood-to-plasma ratio 0.59 (0.02) 0.59 (0.01) 0.58 (0.01)
Blood cell-to-plasma ratio



0.17 (0.004)
0.18 (0.03)
0.15 (0.02)