Effects of TNF-α and IL-6 treatment on expression of referent inflammation markers
Exposure Time to Cytokines | -Fold Induction (mRNA Levels)a | ||
|---|---|---|---|
| IL-8 Expression/TNF-α Treatment | CRP Expression/IL-6 Treatment | ||
| 8 h | 88 ± 59b (8-214)c | 8115 ± 7867 (78-20,355) | |
| 24 h | 104 ± 73 (10-271) | 15,751 ± 14,662 (111-31,108) | |
| 48 h | 96 ± 83 (10-344) | 11,821 ± 11,331 (50-30,786) | |
↵ a Defined as the ratio of mRNA levels in cytokine-treated primary hepatocytes versus those found in untreated counterparts.
↵ b Expressed as mean ± S.E.M. of values from six independent hepatocyte populations.
↵ c Numbers in parentheses indicate the induction range for the six hepatocyte populations analyzed in the study.