Compound | IC50 - NADPH | IC50 + NADPH | IC50 Shift | kinact | KI |
---|---|---|---|---|---|
min-1 | μM | ||||
(±)-Fluoxetine | 22, 37, 22 | 3.3, 3.9, 1.8 | 6.6, 9.4, 12 | 0.031, 0.029, 0.031 | 17, 11, 13 |
(S)-Fluoxetine | 91, 79, 109 | 2.8, 3.3, 4.0 | 33, 24, 28 | 0.075, 0.115, 0.064 | 40, 54, 46 |
(R)-Fluoxetine | 20, 22, 21 | 3.5, 3.9, 4.7 | 5.6, 5.5, 4.4 | 0.026, 0.024, 0.018 | 7.5, 6.8, 5.3 |
(±)-Norfluoxetine | 18 | 1.5 | 11 | N.D. | N.D. |
(S)-Benzylnirvanol | 0.19, 0.16, 0.17 | 0.41, 0.43, 0.44 | 0.46, 0.38, 0.38 | N.A. | N.A. |
Ticlopidine | 1.14, 1.20, 1.43 | 0.81, 0.76, 0.59 | 1.4, 1.6, 2.4 | N.D. | N.D. |
N.A., not applicable; N.D., not done.