TABLE 1

Comparison of amino acid content in P-glycoprotein in human, chimpanzee, rhesus monkey, dog, rat, guinea pig, and mouse


P-gp Proteina

% of Amino Acid Homologyb
Human
Chimpanzee
Rhesus Monkey
Dog
Guinea Pigc
Rat
Mouse
Mouse 87 80 85 83 82 93 100
Rat 85 83 88 83 80 100
Guinea pigc 82 82 82 82 100
Dog 87 89 87 100
Rhesus monkey 93 94 100
Chimpanzee 97 100
Human
100






  • a P-glycoprotein, transcribed from MDR1 (human, chimpanzee, rhesus monkey, dog, and guinea pig) and mdr1a (rat and mouse) genes.

  • b The percentage of identity calculated using Ensembl 45 protein sequences (Hubbard et al., 2007) and Blast 2 sequence comparison (Tatusova and Madden, 1999).

  • c The whole gene sequence is not yet available. The gene was predicted by projecting human Ensembl transcripts through a BLASTZ DNA alignment to the human genome.