Comparison of amino acid content in P-glycoprotein in human, chimpanzee, rhesus monkey, dog, rat, guinea pig, and mouse
P-gp Proteina | % of Amino Acid Homologyb | ||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Human | Chimpanzee | Rhesus Monkey | Dog | Guinea Pigc | Rat | Mouse | |||||||
Mouse | 87 | 80 | 85 | 83 | 82 | 93 | 100 | ||||||
Rat | 85 | 83 | 88 | 83 | 80 | 100 | |||||||
Guinea pigc | 82 | 82 | 82 | 82 | 100 | ||||||||
Dog | 87 | 89 | 87 | 100 | |||||||||
Rhesus monkey | 93 | 94 | 100 | ||||||||||
Chimpanzee | 97 | 100 | |||||||||||
Human | 100 |
|
|
|
|
|
|
↵ a P-glycoprotein, transcribed from MDR1 (human, chimpanzee, rhesus monkey, dog, and guinea pig) and mdr1a (rat and mouse) genes.
↵ b The percentage of identity calculated using Ensembl 45 protein sequences (Hubbard et al., 2007) and Blast 2 sequence comparison (Tatusova and Madden, 1999).
↵ c The whole gene sequence is not yet available. The gene was predicted by projecting human Ensembl transcripts through a BLASTZ DNA alignment to the human genome.