TABLE 5

Average percentage of the tracer not bound to plasma proteins without (w/o) and with (w) cyclosporin A (CsA) administration (S.D., if n ≥ 3)

[11C]Verapamil
[11C]GR205171
[18F]Altanserin
w/o CsA
w CsA
w/o CsA
w CsA
w/o CsA
w CsA
Rat 5.5 (1.9) 6.2 (2.2) 10.5 (0.5) 13.0 (0.6)a <1 <1
Guinea pig 3.5 (1.8) 3.6 (1.4) 9.7 (3.0) 13.9
Minipig <1 <1
Monkey 1 11.3, 9.4b 9.6
Monkey 2 8.4, 8.5b 7.9 11.0
Human
14.9 (1.6)
<1

  • ↵ a Significantly (P < 0.001) higher with CsA than without according to a one-tailed t test.

  • ↵ b Two scans were performed in the same animal. The second value was determined in plasma obtain 1 to 2 min before CsA administration.