Cell Line | Papp | Efflux Ratio (B-A/A-B) | Residual BCRP Activity in Function | ||
---|---|---|---|---|---|
A-B | B-A | ||||
×10-6 cm/s | ×10-6 cm/s | % | |||
Caco-2 wt | 0.94 ± 0.23 | 20.24 ± 2.58 | 21.45 | 100 | |
Caco-2 wt + FTC | 2.45 ± 0.49 | 1.10 ± 0.28 | 0.45 | -2.70 | |
Clone D | 1.33 ± 0.07 | 3.66 ± 0.45 | 2.75 | 8.56 | |
Clone D + FTC | 1.21 ± 0.26 | 0.60 ± 0.10 | 0.49 | -2.48 |
A, apical; B, basolateral; wt, wild-type.