TABLE 1

Summary of MP-GH and testosterone on mouse Ugt mRNA expression in liver and kidney

HX mice were treated with either MP-GH or testosterone. GNX mice were treated with testosterone and lit/lit mice with MP-GH. Up arrow (↑) indicates up-regulation of Ugt mRNA expression as compared with placebo controls. Down arrow (↓) indicates decreased Ugt mRNA expression compared with placebo controls. Multiple arrows indicate amplitude of change. Side arrows (⇆) indicate no significant change in mRNA expression compared with placebo controls.



HX

GNX

lit/lit

MP-GH
Test
Test
MP-GH
Ugt1a1 (liver)
Ugt1a5 (liver)
Ugt2b1 (liver)
Ugt1a2 (kidney) ↓ ↓ ↓ ↓
Ugt2b38 (kidney)


↑ ↑