TABLE 1

List of prototypical MEIs used to activate xenobiotic-responsive transcription factor pathways

Chemicals are sorted by prototypical pathways. Abbreviations, doses, vehicle, and route of administration are also listed.


Chemical

Dose

Vehicle

Route
AhR activators
    TCDD 34 μg/kg Corn oil Intraperitoneal
    PCB126 300 μg/kg Corn oil Intraperitoneal
    β-NF 200 mg/kg Corn oil Intraperitoneal
CAR activators
    TCPOBOP 300 μg/kg Corn oil Intraperitoneal
    DAS 200 mg/kg Corn oil Intraperitoneal
    PB 100 mg/kg Saline Intraperitoneal
PXR activators
    PCN 200 mg/kg Corn oil Intraperitoneal
    SPR 200 mg/kg Corn oil Intraperitoneal
    DEX 75 mg/kg Corn oil Intraperitoneal
PPARα activators
    CLFB 500 mg/kg Corn oil Intraperitoneal
    CPFB 40 mg/kg Corn oil Intraperitoneal
    DEHP 1000 mg/kg Corn oil Oral
Nrf2 activators
    OPZ 150 mg/kg Corn oil Oral
    ETHOXYQ 250 mg/kg Corn oil Oral
    BHA
350 mg/kg
Corn oil
Intraperitoneal