Clearance predictions by NAS
Compound Number | Species Used for Scaling | Allometric Coefficientsa | Predicted Plasma Clearanceb | ||||
|---|---|---|---|---|---|---|---|
| r2 | a (Slope) | b (Intercept) | |||||
| ml/min/kg | |||||||
| 1 | Rat, dog, monkey, rabbit | 0.982 | 0.90 | 1.66 | 4.9 ± 0.7 | ||
| Rat, dog | 0.91 | 1.69 | 4.6 | ||||
| 2 (Raltegravir) | Rat, dog, monkey, rabbit | 0.994 | 0.86 | 1.76 | 3.7 ± 0.3 | ||
| Rat, dog | 0.88 | 1.78 | 4.1 | ||||
| 3 | Rat, dog, monkey, rabbit | 0.973 | 1.15 | 1.19 | 4.0 ± 0.9 | ||
| Rat, dog | 1.22 | 1.28 | 5.4 | ||||
| 4 | Rat, dog, monkey, rabbit | 0.938 | 1.03 | 1.74 | 5.8 ± 1.7 | ||
| Rat, dog | 1.06 | 1.82 | 6.8 | ||||
| 5 | Rat, dog, monkey, rabbit | 0.981 | 1.19 | 1.93 | 7.0 ± 1.3 | ||
| Rat, dog | 1.22 | 1.99 | 7.7 | ||||
| 6 | Rat, dog, rabbit | 0.993 | 1.05 | 1.41 | 1.8 ± 0.3 | ||
| Rat, dog | 1.07 | 1.45 | 2.1 | ||||
| 7 | Rat, dog, monkey | 0.926 | 1.14 | 1.67 | 7.0 ± 4.6 | ||
| Rat, dog | 0.98 | 1.53 | 4.0 | ||||
| 8 | Rat, dog, monkey | 0.996 | 1.35 | 0.51 | 2.0 ± 0.3 | ||
| Rat, dog | 1.32 | 0.48 | 1.7 | ||||
| 9 | Rat, dog, monkey | 0.927 | 1.17 | 0.60 | 1.9 ± 1.0 | ||
| Rat, dog | 1.31 | 0.73 | 3.7 | ||||
| 10 | Rat, dog, monkey | 0.976 | 0.83 | 2.06 | 3.3 ± 0.7 | ||
|
| Rat, dog |
| 0.89 | 2.11 | 4.1 | ||
↵ a Allometric scaling of CLin_invivo was done by linear regression analysis according to eq. 6. The fit parameters a (slope), b (intercept), and r2 (correlation coefficient) are shown.
↵ b Human CLin_invivo was extrapolated from the regression line and used to calculate human CLP. Data represent the calculated CLP ± S.E. S.E. was calculated by propagation of the S.E. of human CLin_invivo obtained by linear regression analysis.