Compound | Enzyme | Current Study | Literature Vmax/Km | ||||||||
---|---|---|---|---|---|---|---|---|---|---|---|
HLM CLint | P450 CLint | RAF | HLM CLint | P450 CLint | RAF | ||||||
μl/min/mg | μl/min/pmol | pmol/mg | μl/min/mg | μl/min/pmol | pmol/mg | ||||||
Phenacetin | CYP1A2 | 27 ± 20 | 4.9 ± 0.3 | 5.6 ± 4.1 | 15 | 1.9 | 8 | ||||
Diclofenac | CYP2C9 | 487 ± 262 | 24 ± 1 | 20 ± 11 | 418 | 25 | 17 | ||||
Midazolam | CYP3A4 | 1073 ± 860 | 23 ± 3 | 47 ± 37 | 537 | 26 | 21 | ||||
Bufuralol | CYP2D6 | 93 ± 58 | 27 ± 6 | 3.4 ± 2.1 | N.A. | N.A. | N.A. | ||||
Mephenytoin | CYP2C19 | N.T. | N.T. | N.T. | 1.0 | 0.5 | 2 |
N.A., not available; N.T., not tested.