TABLE 4

P450 enzyme contribution to the metabolism of 72 reference drugs


P450 Enzyme Contribution

No. of Substrates
One enzyme 41
    CYP3A4 21
    CYP2D6 14
    CYP2C19 2
    CYP2C9 2
    CYP1A2 2
Two enzymes 17
    CYP3A4, -2D6 6
    CYP2D6, -2C19 5
    CYP3A4, -2C19 4
    CYP2C9, -3A4 1
    CYP2D6, -1A2 1
Three enzymes 9
    CYP3A4, -2D6, -2C19 7
    CYP3A4, -2D6, -1A2 1
    CYP2D6, -1A2, -2C19 1
Four enzymes 5
    CYP3A4, -2D6, -1A2, -2C19
5