Classification of compounds used in the screening test
Classification | Compounds | References |
|---|---|---|
| Known hCAR activators | CITCO; artemisinin; phenobarbital; phenytoin; chlorpromazine; carbamazepine; efavirenz; nevirapine | Wang et al., 2003; Yamamoto et al., 2003; Maglich et al., 2003; Simonsson et al., 2006; Faucette et al., 2007 |
| Selective activators of other nuclear receptors | Rifampicin; 3-methylcholanthrene; Wy-14,643; chenodeoxycholic acid; 22(R)-hydroxycholesterol | Tirona and Kim, 2005 |
| Selective mouse CAR activators and known hCAR deactivators | TCPOBOP and meclizine (mCAR activator); clotrimazole; PK11195; okadaic acid | Kawamoto et al., 1999; Honkakoski et al., 2003; Huang et al., 2004 |
| Rodent CYP2B inducers without available CAR information | Fluconazole; diazepam; myclobutanil; butylated hydroxyanisole | Sun and Fukuhara, 1997; Parkinson et al., 2006; Sun et al., 2006, 2007 |