Mdr1a/1b(-/-), (-/-) vs. FVB | Bcrp(-/-) vs. FVB | Mdr1a/1b(-/-), (-/-)Bcrp(-/-) vs. FVB | |||||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Brain | Plasma | CSF | Brain/Plasma | Brain | Plasma | CSF | Brain/Plasma | Brain | Plasma | CSF | Brain/Plasma | ||||||||||
0.5 h | |||||||||||||||||||||
Flavopiridol | 1.79 ± 0.27 | 1.06 ± 0.17 | 1.85 ± 0.21 | 1.67 ± 0.15 | 1.42 ± 0.33 | 1.09 ± 0.28 | 1.51 ± 0.41 | 1.29 ± 0.11 | 10.07 ± 1.87***,### | 1.35 ± 0.12* | 5.81 ± 1.56**,## | 7.35 ± 1.41**,## | |||||||||
Imatinib | 3.37 ± 0.35 | 0.76 ± 0.10 | 1.54 ± 0.34 | 4.45 ± 0.79 | 0.89 ± 0.19 | 0.94 ± 0.09 | 1.11 ± 0.41 | 0.94 ± 0.14 | 19.03 ± 4.27**,## | 0.69 ± 0.11## | 5.80 ± 1.19**,### | 28.23 ± 8.81**,## | |||||||||
PF-407288 | 0.98 ± 0.34 | 0.66 ± 0.20 | 0.78 ± 0.41 | 1.53 ± 0.40 | 1.13 ± 0.33 | 0.79 ± 0.18 | 0.45 ± 0.18 | 1.43 ± 0.14 | 2.70 ± 0.83**,# | 1.34 ± 0.28**,## | 1.88 ± 0.63*,## | 2.02 ± 0.31## | |||||||||
Prazosin | 2.26 ± 0.66 | 1.24 ± 0.33 | 2.47 ± 1.09 | 1.86 ± 0.42 | 1.23 ± 0.09 | 0.92 ± 0.16 | 0.83 ± 0.38 | 1.38 ± 0.32 | 5.67 ± 0.79***,### | 0.96 ± 0.30 | 5.24 ± 1.89*,## | 6.14 ± 1.19**,### | |||||||||
2 h | |||||||||||||||||||||
Flavopiridol | 2.72 ± 1.13 | 1.92 ± 1.01 | 4.45 ± 1.82 | 1.58 ± 0.42 | 1.86 ± 0.35 | 1.42 ± 0.34 | 2.51 ± 0.90 | 1.33 ± 0.09 | 16.85 ± 3.40***,### | 2.50 ± 0.68# | 15.35 ± 7.25*,# | 6.89 ± 0.95***,### | |||||||||
Imatinib | 3.83 ± 1.18 | 0.90 ± 0.35 | N.E. | 4.46 ± 1.07 | 0.84 ± 0.38 | 0.98 ± 0.31 | N.E. | 0.86 ± 0.32 | 50.78 ± 6.96***,### | 0.92 ± 0.36# | N.E. | 63.59 ± 31.78*,# | |||||||||
PF-407288 | 2.10 ± 1.18 | 1.94 ± 0.65 | N.E. | 1.02 ± 0.22 | 1.70 ± 0.26 | 1.43 ± 0.29 | N.E. | 1.19 ± 0.17 | 2.66 ± 0.86 | 1.93 ± 0.60 | N.E. | 1.36 ± 0.23* | |||||||||
Prazosin | 4.33 ± 1.06 | 2.42 ± 0.57 | 1.42 ± 0.10 | 1.75 ± 0.24 | 3.62 ± 0.33 | 3.20 ± 0.36 | 0.43 ± 0.57 | 1.10 ± 0.04 | 22.67 ± 2.25***,### | 4.33 ± 0.73**,# | 8.77 ± 3.58*,## | 5.18 ± 0.78***,### |
N.E., not estimated.
Comparison of concentration ratios of Mdr1a/1b(-/-), (-/-), Bcrp(-/-) vs. FVB and concentration ratios of Mdr1a/1b(-/-), (-/-) vs. FVB: * P < 0.05; ** P < 0.01; *** P < 0.001.
Comparison of concentration ratios of Mdr1a/1b(-/-), (-/-), Bcrp(-/-) vs. FVB and concentration ratios of Bcrp(-/-) vs. FVB: # P < 0.05; ## P < 0.01; ### P < 0.001.