Enzyme, Gender | Relative Level in Germ-Free Compared with Control Rats | ||||||
---|---|---|---|---|---|---|---|
Liver | Small Intestine | Cecum | Colon | ||||
GSTA1/2 | |||||||
Male | 0.9 ± 0.1 | 1.0 ± 0.1 | 3.3 ± 2.4 | 4.0 ± 0.5* | |||
Female | 0.8 ± 0.1 | 0.8 ± 0.4 | 2.6 ± 1.4*** | 5.0 ± 0.3** | |||
GSTA3 | |||||||
Male | 1.4 ± 0.5 | 1.0 ± 0.2 | 1.5 ± 0.6 | 1.6 ± 0.4 | |||
Female | 1.2 ± 0.2 | 1.0 ± 0.2 | 1.0 ± 0.2 | 1.0 ± 0.3 | |||
GSTA4 | |||||||
Male | 0.9 ± 0.5 | 1.0 ± 0.1 | 0.9 ± 0.5 | 1.5 ± 0.3* | |||
Female | 0.7 ± 0.1 | 1.1 ± 0.2 | 1.9 ± 0.5* | 1.9 ± 0.2*** | |||
GSTM1 | |||||||
Male | 1.2 ± 0.2 | 1.0 ± 0.1 | 1.2 ± 0.2 | 1.1 ± 0.3 | |||
Female | 1.2 ± 0.3 | 1.1 ± 0.3 | 0.7 ± 0.2 | 1.5 ± 0.2*** | |||
GSTP1 | |||||||
Male | ∼1a | 0.9 ± 0.1 | 1.0 ± 0.2 | 0.9 ± 0.2 | |||
Female | ∼1a | 1.3 ± 0.3 | 1.0 ± 0.1 | 1.0 ± 0.2 | |||
GSTT2 | |||||||
Male | 0.9 ± 0.1 | 0.5 ± 0.3 | 0.9 ± 0.6 | 1.4 ± 0.4 | |||
Female | 1.0 ± 0.1 | 1.1 ± 1.0 | 0.9 ± 0.2 | 0.7 ± 0.2 | |||
GPX2 | |||||||
Male | 2.0 ± 0.5 | 0.9 ± 0.5 | 1.0 ± 0.4 | 1.2 ± 0.3 | |||
Female | 1.1 ± 0.2 | 1.1 ± 0.3 | 0.7 ± 0.4 | 1.2 ± 0.3 | |||
EPHX1 | |||||||
Male | 1.1 ± 0.2 | 1.0 ± 0.3 | 0.9 ± 0.8 | 3.5 ± 0.2** | |||
Female | 0.7 ± 0.3 | 1.1 ± 0.4 | 1.5 ± 0.3** | 2.4 ± 0.2** | |||
EPHX2 | |||||||
Male | 1.1 ± 0.2 | 0.8 ± 0.5 | 1.1 ± 0.2 | 1.4 ± 0.2 | |||
Female | 1.6 ± 0.4* | 1.0 ± 0.3 | 2.1 ± 0.6** | 2.1 ± 0.1** | |||
SULT1A1 | |||||||
Male | 1.6 ± 0.1*** | — | — | — | |||
Female | 1.5 ± 0.2** | — | — | — | |||
SULT1B1 | |||||||
Male | 0.9 ± 0.2 | — | 0.9 ± 0.1 | 0.4 ± 0.4* | |||
Female | 1.0 ± 0.2 | — | 2.0 ± 0.8* | 0.5 ± 0.1* | |||
SULT1C1 | |||||||
Male | 1.7 ± 0.3* | — | — | — | |||
Female | 2.6 ± 0.9** | — | — | — | |||
SULT1C2 | |||||||
Male | 1.9 ± 0.8* | — | 0.9 ± 0.3 | 1.3 ± 0.6 | |||
Female | 1.7 ± 0.1** | — | 2.2 ± 1.2 | 1.6 ± 0.2* | |||
SULT1E1 | |||||||
Male | 1.1 ± 0.1 | — | — | — | |||
Female | — | — | — | — | |||
SULT2A | |||||||
Male | 1.0 ± 0.5 | — | — | — | |||
Female | 1.0 ± 0.1 | — | — | — | |||
NAT1 | |||||||
Male | 1.1 ± 0.3 | 0.8 ± 0.5 | 1.2 ± 0.3 | 1.7 ± 0.1* | |||
Female | 0.9 ± 0.2 | 0.9 ± 0.2 | 1.3 ± 0.3 | 2.2 ± 0.3** | |||
NAT2 | |||||||
Male | — | — | 2.2 ± 0.8* | 1.4 ± 0.3 | |||
Female | — | — | 2.9 ± 1.0** | 1.5 ± 0.2* |