Compound | Vu,brain Meana | Vu,brain 95% CIRb | Compound Recovery | Variance Componentsc | ||||||
---|---|---|---|---|---|---|---|---|---|---|
Days | Rats | Slices | Analytical | |||||||
ml · brain-1 | % | % total variability | ||||||||
Diazepam | 19.6 | 1.132 | 94.5 ± 3.2 | 10.5 | 2.5 | 37.4 | 49.7 | |||
Gabapentin | 4.48 | 1.484 | 102 ± 9.5 | 30.0 | 12.7 | 0 | 57.3 | |||
Indomethacin | 13.0 | 1.136 | 88.2 ± 8.8 | 13.1 | 23.4 | 36.5 | 26.9 | |||
Paroxetine | 862 | 1.149 | 97.1 ± 4.6 | 18.7 | 0.0 | 46.2 | 35.1 | |||
Thioridazine | 2617 | 1.203 | 103 ± 8.6 | 9.7 | 0.0 | 51.1 | 39.1 |
↵ a The mean is a geometric mean, the antilog of the mean of the logs.
↵ b The 95% CIR is the confidence interval ratio; the 95% confidence interval is the ratio of the mean divided by the CIR to the mean multiplied by the CIR. The tabulated CIR refers to a single analysis of a single slice.
↵ c Total variability is defined as the variability (variance) of a single observation. It is the sum of all the variance components.