TABLE 4

E_max,relative and EC₅₀ values of inducers determined by in vitro reporter gene assay

Previous reports on the in vitro reporter gene assay were surveyed to summarize the E_max,relative and EC₅₀ values of phenobarbital, phenytoin, carbamazepine, and omeprazole.

Inducer	E_max,relative	Unbound EC₅₀	Mean E_max,relative	Mean Unbound EC₅₀	Ref.^a
	%	μM	%	μM
Pentobarbital	71.7	157	80.0	251	37
	88.3	344			40
Phenytoin	21.6	4.02			37
Omeprazole	147	3.54			37
Carbamazepine	22.7	12.8	50.3	25.6	37
	77.9	38.4			41

↵ a See Supplemental Data Appendix reference.