TABLE 6

List of parameter values used in the present study

Criteria for the use of other parameter values are described in the text.

Rifampicin
Phenobarbital
Phenytoin
Carbamazepine
Omeprazole
ka (h-1)a 0.97 1.8 1.1 0.78 0.61
f P 0.30 0.49 0.11 0.26 0.050
ke (h-1) 0.27 0.0070 0.046 0.027 0.99
Vd/F (l/kg) 1.1b 0.54 0.71 1.4 0.64
Qpv (l/h)
77
77
77
77
77

  • ↵ a Predicted from Japanese package inserts.

  • ↵ b Assumed that the bioavailability F is 0.9.