TABLE 1

Unbound fractions (fu) for the binding of phenytoin, propofol, and propranolol to BSA and IFABP


Drug

Protein

Drug Concentration

fu at Protein Concentration of:
0.05%
0.1%
0.25%
0.5%
Phenytoin BSA 5 0.97 0.83 0.61 0.45
20 0.97 0.81 0.61 0.48
100 0.96 0.81 0.63 0.47
IFABP 5 0.88 0.78 0.69 0.63
20 0.88 0.78 0.68 0.62
100 0.88 0.80 0.71 0.65
Propofol BSA 25 0.76 0.68 0.59 0.50
100 0.83 0.65 0.62 0.48
500 0.79 0.78 0.58 0.49
IFABP 25 0.98 0.95 0.94 0.97
100 0.98 0.95 0.94 0.92
500 0.98 0.94 0.95 0.92
Propranolol BSA 5 0.89 0.88 0.85 0.71
25 0.92 0.88 0.81 0.71
100 0.93 0.90 0.88 0.77
IFABP 5 0.94 0.90 0.93 0.89
25 0.94 0.89 0.87 0.89


100
0.97
0.91
0.90
0.88