TABLE 2

Unbound fractions (f_u) for the binding of drugs to BSA and IFABP (0.5%)

Drug	Classification	Drug Concentration	f_u in the Presence of:
Drug	Classification	Drug Concentration				IFABP	BSA
Frusemide	Acid	100	0.78	0.19
		1000	0.81	0.20
		5000	0.79	0.24
Naproxen	Acid	10	0.74	0.05
		100	0.78	0.10
		500	0.85	0.04
Phenytoin	Acid	5	0.63	0.45
		20	0.62	0.49
		100	0.65	0.47
Sulfinpyrazone	Acid	10	0.41	0.05
		50	0.41	0.06
		100	0.51	0.13
Torsemide	Acid	5	0.80	0.06
		25	0.80	0.04
		100	0.78	0.11
Lignocaine	Base	100	0.98	0.88
		300	0.96	0.89
		1000	0.93	0.91
Nortriptyline	Base	1	0.93	0.53
		10	0.96	0.48
		100	0.88	0.47
Propranolol	Base	5	0.89	0.71
		25	0.89	0.71
		100	0.88	0.77
Caffeine	Neutral	10	0.89	0.81
		50	0.87	0.84
		100	0.88	0.83
		250	0.89	0.84
Diazepam	Neutral	50	0.81	0.38
		100	0.77	0.39
		200	0.81	0.39
		1000	0.83	0.41
β-Estradiol	Neutral	5	0.59	0.11
		25	0.54	0.12
		100	0.54	0.09
Propofol	Neutral	25	0.97	0.50
		100	0.92	0.48
		500	0.92	0.49
Zidovudine	Neutral	100	1.00	0.95
		1000	0.97	0.96
		3000	0.94	0.92