Kinetic parameters for AZT glucuronidation by HLMs in the absence and presence of IFABP and BSA (0.5, 1.5, and 2.5%)
Control refers to incubations of HLM conducted in the absence of BSA and IFABP.
Parameter | Control | IFABP | BSA | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| 0.5% | 1.5% | 2.5% | 0.5% | 1.5% | 2.5% | ||||||
| K m | 974 | 362 | 137 | 74 | 113 | 78 | 69 | ||||
|
V
max
| 671 | 703 | 682 | 728 | 604 | 697 | 736 | ||||
Km, μM; Vmax, pmol/min · mg.