Probe Substrate to Evaluate NME As an Inducer | ||||
---|---|---|---|---|
P450 Isoform | Substratea | Recommended Dose and Route | ||
CYP1A2 | Theophylline, caffeine | 200 mg oral | ||
CYP2B6 | Bupropion,b efavirenz | 150 mg oral | ||
CYP2C8 | Rosiglitazone, repaglinide | 8 mg oral | ||
CYP2C9 | Warfarin, tolbutamide | 2 to 5 mg oral | ||
CYP2C19 | Omeprazole, esomeprazole, lansoprazole, pantoprazole | 20 mg oral | ||
CYP2E1b | Chlorzoxazone | 500 mg oral | ||
CYP3A4/3A5 | Midazolam, buspirone, felodipine, lovastatin, eletriptan, sildenafil, simvastatin, triazolam | 10 mg oral |