TABLE 1

Drugs and other compounds known to cause time-dependent inhibition of drug-metabolizing human cytochrome P450 enzymes


1-Aminobenzotriazole (several)

Methoxsalen (CYP2A6)
Amiodarone (CYP3A) 3,4-Methylenedioxymethamphetamine (CYP2D6)
Amprenavir (CYP3A) 3-Methylindole (CYP2F)
Azamulin (CYP3A) Mibefradil (CYP3A)
Azithromycin (CYP3A) Midazolam (CYP3A)
Bergamottin (CYP3A) Mifepristone (CYP3A)
Cannabidiol (CYP3A) Nefazodone (CYP3A)
Carbamazepine (CYP1A2) Nelfinavir (CYP3A)
Chlorgyline (CYP1A2) Nicardipine (CYP3A)
Cimetidine (CYP2D6) Paroxetine (CYP2D6)
Clarithromycin (CYP3A) Phencyclidine (CYP2B6)
Clopidogrel (CYP2B6) Phenelzine (several)
Delavirdine (CYP3A) Pioglitazone (CYP3A)
Diclofenac (CYP3A) n-Propylxanthate (CYP2B6)
Dihydralazine (CYP1A2) Raloxifene (CYP3A)
6,7-Dihydroxybergamottin (CYP3A) Resveratrol (CYP3A)
Diltiazem (CYP3A) Rhapontigenin (CYP1A1)
Disulfiram (CYP2E1) Ritonavir (CYP3A)
Efavirenz (CYP2B6) Rofecoxib (CYP1A2)
EMTPP (CYP2D6) Rosiglitazone (CYP3A)
Enoxacin (CYP1A2) Roxithromycin (CYP3A)
Erythromycin (CYP3A) Rutaecarpine (CYP1A1, 1B1)
Ethinyl estradiol (CYP3A) Saquinavir (CYP3A)
2-Ethynylnaphthalene (CYP1A) Silybin (CYP3A)
Fluoxetine (CYP3A) Suprofen (CYP2C9)
Furafylline (CYP1A2) Tabimorelin (CYP3A)
Gemfibrozil glucuronide (CYP2C8) Tamoxifen (CYP3A)
Gestodene (CYP3A) ThioTEPA (CYP2B6)
Glabridin (CYP2B6) Ticlopidine (CYP2B6, 2C19)
Hydrastine (several) Tienilic acid (CYP2C9)
4-Ipomeanol (CYP3A) Troglitazone (CYP3A, 2C8, 2C9)
Irinotecan (CYP3A) Troleandomycin (CYP3A)
Isoniazid (several) Verapamil (CYP3A)
Lopinavir (CYP3A) Zafirlukast (CYP3A)
Menthofuran (CYP2A6)
Zileuton (CYP1A2)
  • EMTPP, (1-[(2-ethyl-4-methyl-1H-imidazol-5-yl)methyl]-4-[4-(trifluoromethyl)-2-pyridinyl]piperazine.