TABLE 4

Summary of estimates of turnover half-lives for cytochrome P450 enzymes in humans ( Yang et al., 2008 )


Enzyme

Range of t1/2 Values

Estimated from in Vitro Data
Estimated from in Vivo Data
hr
CYP1A2 36-51 39-105
CYP2B6 32 No data
CYP2C8 23 No data
CYP2C9 104 No data
CYP2C19 26 No data
CYP2D6 70 51
CYP2E1 27 50-60
CYP3A4
26-79
36-140