Dose-dependent uptake clearance of HbV in liver, spleen, kidney, lung, and heart after 125I-HbV administration in mice
All mice received a single injection of 125I-HbV (1, 10, 200, and 1400 mg of Hb/kg) containing 5% rHSA. The uptake clearance for each organ was calculated by integration plot analysis at designated times from 1 to 30 min after injection. Values are mean ± S.D. (n = 3–6).
Dose | CLuptake | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| Liver | Spleen | Kidney | Lung | Heart | |||||
| μl/h | |||||||||
| 1 mg of Hb/kg | 2608 ± 654 | 1018 ± 188 | 19 ± 9.4 | 3.5 ± 0.9 | 0.14 ± 0.06 | ||||
| 10 mg of Hb/kg | 1473 ± 440 | 786 ± 94 | 18 ± 8.1 | 2.5 ± 0.2 | 0.38 ± 0.09 | ||||
| 200 mg of Hb/kg | 452 ± 114 | 102 ± 36 | 25 ± 9.2 | 1.3 ± 0.2 | 0.06 ± 0.02 | ||||
| 1400 mg of Hb/kg | 256 ± 37 | 51 ± 6.1 | 27 ± 9.4 | 0.6 ± 0.2 | 0.14 ± 0.06 | ||||