TABLE 4

Pharmacokinetic parameters of MDZ after administration of a 4-mg p.o. dose or a 0.05-mg/kg i.v. dose of MDZ before and after pretreatment with DTZ SR (Cardizem SR, 120 mg twice daily) for 7 days to three volunteers

Data are mean ± S.D.



Oral MDZ

Intravenous MDZ

Before
After
p
Before
After
p
Cmax (mg/l) 15.8 ± 2.8 41.3 ± 14.0 <0.05 87.3 ± 6.1 112.7 ± 9.0 <0.05
Tmax (h) 1.3 ± 0.7 1.9 ± 0.2 0.18 0.5 0.5 N.A.
AUC0-∞ (mg · h/l) 69 ± 15.7 276.7 ± 33.3 <0.05 216.3 ± 58.5 372.0 ± 58.0 <0.05
t1/2 (h)
6.0 ± 1.7
8.0 ± 0.8
0.23
2.7 ± 0.7
4.1 ± 0.62
0.13
  • N.A., not applicable.