TABLE 1

Mass balance results in mice, rats, rabbits, dogs, and humans after a single oral dose of [¹⁴C]apixaban

Species	Dose^a	No. of Subjects	Matrix	Sampling Time	Recovery
				h	% dose
Mouse	30 mg/kg	5	Urine	0-48	15.2
			Feces	0-48	83.9
			Total	0-48	99.1
Rat	30 mg/kg	Intact 3	Urine	0-168	13.4
			Feces	0-168	74.0
			Total	0-168	87.4
		BDC 3	Bile	0-48	2.6
			Urine	0-48	10.5
			Feces	0-48	69.8
			Total	0-48	82.9
Rabbit	30 mg/kg	3	Urine	0-48	1.8
			Feces	0-48	54.3
			Total	0-48	56.1
Dog	5 mg/kg	3	Urine	0-168	8.8
			Feces	0-168	73.7
			Total	0-168	82.5
Human	20 mg	No bile collection 6	Urine	0-292	25.1
			Feces	0-292	56.0
			Total	0-292	80.5
		Bile collection 4	Bile	3-8	2.4
			Urine	0-216	28.8
			Feces	0-216	46.7
			Total	0-216	77.9

↵ a Radiospecific activities of [¹⁴C]apixaban used were 5 μCi/mg for mice, 5 μCi/mg for rats (oral), 1.5 μCi/mg for rabbits, 5 μCi/mg for dogs, and 5.4 μCi/mg for humans. Human data have been presented previously (Raghavan et al., 2009) and were included here for comparison only.