Comparison of the effect of various compounds on TC transport by BSEP in high and low cholesterol membrane environment
BSEP-Control | BSEP-HAM | ||
|---|---|---|---|
| IC50/μM | |||
| Troglitazone | 8.4 | 9.5 | |
| CsA | 2.0 | 18.9 | |
| Glibenclamide | 11.3 | 14.7 | |
| Valinomycin | 0.7 | 1.0 | |
| Vinblastine | 57.3 | 62.0 | |
| Rifampicin | 10.5 | 18.8 | |
| Clofazimine | 2.3 | 5.4 | |
| Reserpine | 2.8 | 4.9 | |
| Ethinyl-estradiol | 15.7 | 17.1 | |