TABLE 1

Characteristics of 15 solute carrier transporters investigated in this study


Full Name

Acronym

SLC Code

Tissue Expression

Substrate Specificity

Reported/Implicated Association with Inflammation in

Reported/Implicated Association with IBD

References
Apical sodium-dependent bile acid transporter ASBT SLC10A2 Small intestine, biliary epithelium, kidney Bile acids Human colonic cell line Yes Jung et al., 2004; Neimark et al., 2006
Concentrative nucleoside transporter 1 CNT1 SLC28A1 Jejunum, kidney, liver, small intestine, brain Nucleosides, nucleoside analogs Rat hepatocytes No Fernández-Veledo et al., 2004; Podgorska et al., 2005
Concentrative nucleoside transporter 2 CNT2 SLC28A2 Kidney, liver, intestine, jejunum, heart, brain, Nucleosides, nucleoside analogs Human primary epithelial cells No Podgorska et al., 2005; Hirsh et al., 2007
Concentrative nucleoside transporter 3 CNT3 SLC28A3 Bone marrow, pancreas, trachea, mammary gland, placenta Nucleosides, nucleoside analogs Human primary epithelial cells No Podgorska et al., 2005; Hirsh et al., 2007
Equilibrative nucleoside transporter 1 ENT1 SLC29A1 Ubiquitous Nucleosides, nucleoside analogs None No Podgorska et al., 2005; Santini et al., 2008
Equilibrative nucleoside transporter 2 ENT2 SLC29A2 Ubiquitous Nucleosides, nucleoside analogs None No Podgorska et al., 2005
Organic anion transporter 2 OAT2 SLC22A7 Liver, kidney, adipose tissue Organic anions None No Burckhardt and Wolff, 2000
Organic anion-transporting polypeptide 1A2 OATP1A2 SLCO1A2 Brain (endothelial cells), kidney, liver Bile salts, organic anions and cations None No Hagenbuch and Meier, 2004
Organic anion-transporting polypeptide 2B1 OATP2B1 SLCO2B1 Liver, placenta E-3-S, DHEAS Human primary hepatocytes No Hagenbuch and Meier, 2004; Le Vee et al., 2008
Organic anion-transporting polypeptide 4A1 OATP4A1 SLCO4A1 Ubiquitous Taurocholate, prostaglandin None No Hagenbuch and Meier, 2004
Organic cation transporter 1 OCT1 SLC22A1 Liver Organic cations None No Burckhardt and Wolff, 2000; Koepsell et al., 2007
Organic cation/zwitterion transporter 1 OCTN1 SLC22A4 Kidney, intestine, heart, skeletal muscle, placenta Organic cations None Yes Russell et al., 2004; Waller et al., 2006; Cucchiara et al., 2007; Silverberg et al., 2007; Noble et al., 2008
Organic cation/zwitterion transporter 2 OCTN2 SLC22A5 Kidney, intestine, heart, skeletal muscle, placenta Organic cations, carnitine Experimental colitis in mice and rats Yes D'Argenio et al., 2006; Russell et al., 2006; Waller et al., 2006; Cucchiara et al., 2007; Shekhawat et al., 2007; Silverberg et al., 2007; Noble et al., 2008
Peptide transporter 1 PEPT1 SLC15A1 Intestine, kidney Di- and tripeptides Human intestinal cell lines Yes Daniel and Kottra, 2004; Vavricka et al., 2006; Dalmasso et al., 2008
Serotonin transporter
SERT
SLC6A4
Brain, small intestine
Serotonin
Experimental colitis in mice; human intestine-derived cell line
No
Linden et al., 2005; Coates et al., 2006; Foley et al., 2007
  • E-3-S, estrone-3-sulfate; DHEAS, dihydroepiandrosterone.