TABLE 4

Studies of therapeutic agents, abused drugs and food contaminants transfer using in vivo and in vitro models of placenta

Perfused Human PlacentaIn Vivo Transplacental TransferBeWoJeg-3JAR
Intracellular AccumulationVectorial TransportIntracellular AccumulationVectorial TransportIntracellular AccumulationVectorial Transport
Physiological moleculesndndndAmino acid,e glucose,f glucocorticoids,g folic acid,g fatty acid,h transferrin,i serotonin,j bilirubin,j choline,k IgG,k cholesterol,l leptinmndCopperuFolic acidvnd
Abused agentsCocaine, alcohol, nicotine, morphine
Medicinal drugsHIV inhibitors, antidepressants,Antiviral drugs, antimitotic, colchicines, HIV inhibitors, antidepressants, antibiotics, antacid, antidiabetic,LevofloxacincValproic acidnNitrofurantoinwnd
Antibiotics, antacid, antidiabeticAnesthetics, antiepileptic, heart conditionaRiboflavindOpioid peptides,o vincristine, vinblastine, digoxin,p monocarboxylic acidq
Anesthetics, antiepileptic, heart condition
Pregnancy related treatmenta,b
Food contaminantCaffeine, glyphosate, benzoic acid,s PhIPtndCaffeine, glyphosate, benzoic acidrndndnd

  • nd, no data available.

  • ↵a Rama Sastry, 1999;

  • ↵b Myren et al., 2007;

  • ↵c Polachek et al., 2010;

  • ↵d Huang and Swaan, 2001;

  • ↵e Jones et al., 2006;

  • ↵f Vardhana and Illsley, 2002;

  • ↵g Takahashi et al., 2001;

  • ↵h Liu et al., 1997;

  • ↵i van der Ende, 1990;

  • ↵j Pascolo et al., 2001;

  • ↵k Ellinger et al., 1999;

  • ↵l Schmid et al., 2003;

  • ↵m Wyrwoll et al., 2005;

  • ↵n Utoguchi and Audus, 2000;

  • ↵o Ampasavate et al., 2002;

  • ↵p Ushigome et al., 2000;

  • ↵q Utoguchi et al., 1999;

  • ↵r Poulsen et al., 2009;

  • ↵s Mose et al., 2008;

  • ↵t Myllynen et al., 2008;

  • ↵u Hardman et al., 2007;

  • ↵v Keating et al., 2006;

  • ↵w Feinshtein et al., 2010.