Physiological Parameters and Scaling Factors | Rat | Human |
---|---|---|
fu | 0.003a | 0.004b |
Hepatic protein content mg protein/g of liver | 200c | 71d |
Relative liver weight g liver/kg b.wt. | 40c | 26d |
QH [ml/(min · kg)] | 40c | 21d,f |
In vivo plasma clearance [ml/(min · kg)] | 1.25g | 0.229h |
In vitro intrinsic uptake clearance [ml/(min · mg protein)] | 0.0190 ± 0.0044 | 0.0235 ± 0.0016 |
Intrinsic uptake clearance [ml/(min · kg)] | 152.4 ± 35.3 | 43.38 ± 2.95 |
Calculated in vivo plasma clearance [ml/(min · kg)] | 0.447 ± 0.104 | 0.175 ± 0.012 |
In vivo biliary clearance [ml/(min · kg)] | 0.085g | 0.16e |
In vitro intrinsic biliary clearance [ml/(min · kg)] | 0.019 ± 0.005 | 0.014 ± 0.009 |
Intrinsic biliary clearance [ml/(min · kg)] | 149.3 ± 41.1 | 25.54 ± 15.69 |
Calculated in vivo biliary clearance [ml/(min · kg)] | 0.438 ± 0.120 | 0.101 ± 0.062 |
↵a Data from Abe et al. (2008a).
↵b Data from S. B. Yanni, P. B. Smith, D. K. Benjamin, P. Augustijns, D. R. Thakker, and P. P. Annaert, manuscript submitted for publication.
↵c Data from Abe et al. (2008c).
↵d Data from Ghibellini et al. (2007).
↵e Data for Mycamine (micafungin sodium) from Astellas Pharma US Inc. [full prescribing information (§12.3. Pharmacokinetics), http://www.astellas.us/docs/mycamine.pdf].
↵f Data from Björkman (2005).
↵g Data from Abe et al. (2008b).
↵h Data from Wiederhold and Lewis (2007).