TABLE 1

Recovery of radioactivity in mice, rats, and dogs after a single oral administration of [14C]casopitant

Results are reported as mean (unless stated otherwise) ± S.D. Data are presented to one decimal place and are computer-generated and rounded appropriately. As a consequence, calculations of values yield minor deviations.

MatrixMice (50 mg/kg)Rats (15 mg/kg)Dogs (10 mg/kg)
Male: Intact (n = 6)Female: Intact (n = 6)MaleFemaleMaleFemale: Intact (n = 2)
Intact (n = 3)BDC (n = 2)Intact (n = 3)BDC (n = 2)Intact (n = 3)BDC (n = 2)
Urine5.4 ± 5.26.9 ± 4.43.4 ± 0.34.61.5 ± 0.11.75.9 ± 0.55.45.8
Feces84.9 ± 10.586.7 ± 9.196.4 ± 2.733.397.6 ± 1.251.682.5 ± 1.725.5–55.4a85.5
BileN.D.N.D.N.D.56.5N.D.38.1N.D.24.7–65.2aN.D.
Cage Wash8.4 ± 6.55.9 ± 7.20.00.00.00.31.6 ± 1.00.21.2
Carcass0.4 ± 0.20.7 ± 0.40.4 ± 03.52.1 ± 0.26.9N.D.N.D.N.D.
Totalb99.2 ± 6.5100 ± 4.5101 ± 3.497.9102 ± 1.098.990.1 ± 1.185.8–96.2a92.5
  • N.D., not determined.

  • a Individual values have been reported because there were notable differences in the extent of elimination between the two animals.

  • b The total collection period was 0 to 168 h for mice and rats (intact), 0 to 96 h for rats and dogs (BDC), and 0 to 216 h for dogs (intact).