TABLE 2

Physicochemical properties of the compounds studied

CompoundClassaclogPcpKa1cpKa2
CefotetanA2.341.692.64
CefazolinA1.132.6011.40
CefpiramideA0.072.629.47
CefoperazoneA1.432.629.49
FurosemideA3.003.049.79
DiclofenacA4.064.18
RosuvastatinA0.424.25
FluvastatinA3.624.27
WarfarinA3.424.50
EthinylestradiolN4.5210.24
CyclosporineN3.35
TC1N2.841.90
TC2N2.572.14
TC3N1.792.15
DiazepamN2.963.40
TC4N6.334.893.87
TC5N2.825.09
MidazolamN3.935.56
TC6N2.865.75
TC7N3.985.92
TC8N3.205.93
NicardipineN5.137.292.61
TC9B2.488.033.01
ErythromycinB2.838.16
LidocaineB2.368.531.62
VerapamilB3.908.97
PropranololB3.109.14
MetoprololB1.799.17
QuinidineB3.449.284.77
PropafenoneB3.939.29
IrinotecanB4.679.335.43
ImipramineB4.809.49
CitalopramB2.519.57
DisopyramideB2.8610.103.71
NaltrexoneZ1.809.167.53
DasatinibZ3.3910.946.59
  • A, acids; B, bases; N, neutrals; Z, zwitterions.

  • a Compounds were considered to be neutral if they were primarily un-ionized around physiological pH, i.e., pKa < 7.4 for bases and pKa > 7.4 for acids.