TABLE 2 Ketoconazole IC50 values for metabolism of CYP3A substrates in monkey intestinal and liver microsomes
Seven CYP3A substrates (200 nM, final concentration) were incubated at 37°C for 15 min with pooled intestinal and liver microsomes from cynomolgus monkeys (MIM and MLM) in the absence or presence of various concentrations of ketoconazole, respectively. Each value presents the mean of duplicate measurements.