Fg, monkey(observed) and Fg, human(predicted) for nine CYP3A substrates calculated from pharmacokinetic parameters in cynomolgus monkeys
Fg, monkey(observed) was calculated from eq. 4 and Fg, human(predicted) from eq. 10. Each value for Fg, monkey(observed) represents the mean ± S.D. of four monkeys.
| Fg, monkey(observed) | Fg, human(predicted) | |
|---|---|---|
| Buspirone | 0.08 ± 0.05 | 0.13 |
| Carbamazepine | 1.00 ± 0.17a | 1.00 |
| Diazepam | 0.67 ± 0.29 | 0.82 |
| Felodipine | 0.37 ± 0.09 | 0.50 |
| Midazolam | 0.26 ± 0.13 | 0.38 |
| Nicardipine | 0.33 ± 0.08 | 0.58 |
| Nifedipine | 0.34 ± 0.26 | 0.59 |
| Saquinavir | 0.16 ± 0.19 | 0.35 |
| Verapamil | 0.39 ± 0.43 | 0.70 |
↵a The calculated value was greater than 1.