Midazolam conc. | Hepatocellular Rate of Formation | Microsomal Rate of Formation | ||||
---|---|---|---|---|---|---|
1′-OH-midazolam | 4-OH-midazolam | Ratio 4-OH/1′-OH | 1′-OH-midazolam | 4-OH-midazolam | Ratio 4-OH/1′-OH | |
pmol/min/g liver | ||||||
5 μM | 5.3 ± 1.3 | 12.7 ± 4.2 | 2.4 | 7.6 ± 2.8 | 19.9 ± 7.6 | 2.6 |
15 μM | 9.9 ± 1.5 | 25.4 ± 6.9 | 2.6 | 9.0 ± 4.1 | 33.9 ± 12.8 | 2.9 |
30 μM | 11.2 ± 1.4 | 29.6 ± 7.9 | 2.6 | 12.5 ± 4.3 | 37.2 ± 12.9 | 2.9 |