TABLE 5

Comparison of hepatocyte and microsomal parameters for distribution, inhibition, and metabolism

InhibitorKpKpuKi (Microsomal/Hepatocellular Ratio)
1′-OH-midazolam4-OH-midazolamTheophylline Hydroxylation
Enoxacin20a23
Clarithromycin22a6.1c1311
Saquinavir306b6.8b0.440.23
Nelfinavir3352b5.7b0.160.28
  • a Data from Yamano et al. (1999).

  • b Data from Parker and Houston (2008).

  • c Y. Yabe, unpublished data.