TABLE 2

Rat/human ratios determined from mass spectrometric peak area ratios with high confidence that the nominal concentration ratio of rat vs. human ≥1

MetaboliteMeasured MS Ratio (When Nominal Ratio = 1)MS Ratio (n = 6) (When Nominal Ratio ≥1)MS Ratio (n = 3) (When Nominal Ratio ≥1)MS Ratio (n = 1) (When Nominal Ratio ≥1)
P < 0.05P < 0.01P < 0.05P < 0.01P < 0.05P < 0.01
M11.522.012.202.272.593.174.20
M21.321.541.621.651.771.982.31
M51.371.681.791.832.012.312.83
M91.221.391.441.461.551.701.92
M101.381.681.791.822.002.302.80
Ziprasidone1.311.551.631.661.802.022.39
Average ratio1.341.631.741.771.942.232.71